INVESTIGADORES
YEVES Alejandra Del Milagro
artículos
Título:
Physiological cardiac hypertrophy: Critical role of AKT in the prevention of NHE-1 hyperactivity
Autor/es:
YEVES AM; VILLA ABRILLE MC; PEREZ NG; MEDINA AJ; ESCUDERO EM; ENNIS IL
Revista:
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
Editorial:
ACADEMIC PRESS LTD-ELSEVIER SCIENCE LTD
Referencias:
Lugar: Amsterdam; Año: 2014 vol. 76 p. 186 - 195
ISSN:
0022-2828
Resumen:
Abstract
Background
The
involvement of NHE-1 hyperactivity, critical for pathological cardiac
hypertrophy (CH), in physiological CH has not been elucidated yet.
Stimulation of NHE-1 increases intracellular Na+ and Ca2 + favouring calcineurin
activation. Since myocardial stretch, an activator of NHE-1, is common
to both types of CH, we speculate that NHE-1 hyperactivity may also
happen in physiological CH. However, calcineurin activation is
characteristic only for pathological hypertrophy. We hypothesize that an
inhibitory AKT-dependent mechanism prevents NHE-1 hyperactivity in the
setup of physiological CH.
