c-fos activates Glucosylceramide synthase and glycolipid synthesis in PC12 cells

CRESPO, PILAR MARÍA; SILVESTRE DAVID; GIL, GERMÁN; MACCIONI, HUGO J.F.; DANIOTTI, JOSÉ LUIS; CAPUTTO BEATRIZ L

JOURNAL OF BIOLOGICAL CHEMISTRY

Año: 2008 vol. 283 p. 31163 - 31171

0021-9258

It has been demonstrated that c-Fos has, in adittion to its well recognized AP-1transcription factor activity, the capacity to associate to the endoplasmic reticulum and activate key enzymesinvolved in the synthesis of phospholipids requerid for membrane biogenesis during cell growth and neurite formation. Because membrane genesis require