Soluble CD163 performance as a suitable non-invasive biomarker of liver damage in chronically HCV and HCV/HIV infected subjects

VICTORIA CAIROLI; ELENA DE MATTEO; PAOLA CASCIATO; BEATRIZ AMEIGEIRAS; MARÍA VICTORIA PRECIADO*; PAMELA VALVA*. * EQUALLY CONTRIBUTED

PLOS ONE

PUBLIC LIBRARY SCIENCE

Lugar: San Francisco; Año: 2022 vol. 7

1932-6203

Macrophage activation plays a key role in liver disease progression. Soluble CD163 (sCD163) is a specific macrophage activation biomarker useful for clinical estimating damage severity and predicting outcome in different liver conditions. sCD163 performance as a non-invasive marker of liver damage was evaluated in plasma samples at time of biopsy in 120 patients with different hepatic conditions (56 HCV, 20 HCV/HIV, 10 HBV and 34 MAFLD). sCD163 values were compared with those of healthy donors and analyzed related to histological damage. sCD163 together with other clinical parameters were used to create a logistical regression model to predict significant fibrosis.Only patients with viral hepatitis showed higher sCD163 values compared to the control group (HCV p