Studies on the neuro-immune-endocrine interactions during pulmonary or pleural tuberculosis

D´ATTILIO L; SANTUCCI N; DIAZ A; BONGIOVANNI B; DIDOLI G; BERTOLA D; GARDEÑEZ W; BOTTASSO O; BAY

Buenos Aires

Congreso; LXIII Argentinean Society for Immunology Meeting; 2015

Sociedad Argentina de Inmunología

Tuberculosisis a major health problem worldwide, mostly affecting the lungs, although pleuraltuberculosis (TBPL) can be a frequent extrapulmonary manifestation. The natural course of both clinical forms isdifferent, partly because of the type of immune responsedeveloped in the two compartments. The immune system receives and sendsmessages to the central nervous system modulatingeach other, through the Hypothalamus Pituitary Adrenal axis and the autonomous nervous system (ANS). To getsome insight on the complex neuro-immune-endocrine (NIE) interactions encompassingTB, we analyzed the relationship between compounds from the ANS (A: adrenaline;NA: noradrenaline and D: Dopamine; -HPLC-), the endocrine system (Cortisol, dehydroepiandrosterone-DHEA and DHEA-S, Growth hormone -GH- and IGF-1; -ELISA-) and immune mediators (IL-1B, IL-6, TNF-a, IL-1B, IFN-g, TGF-B; -ELISA-)in plasma (P) and pleural fluid (PF) of patients with TBP (n=51), TBPL (n=12) andhealthy controls (n=27). Both patient groups had increased amounts of pro-and anti-inflammatory cytokines (p