Increased frequency of CD4+ CD25+ FoxP3+ T regulatory cells in pulmonary tuberculosis patients undergoing specific treatment and its relationship with their immune-endocrine profile

DIAZ A; SANTUCCI N; BONGIOVANNI B; DATTILIO L; MASSONI C; LIOI S; RADCLIFFE S; DIDOLI G; BOTTASSO O; BAY ML

Journal of Immunology Research

HINDAWI

Lugar: New York; Año: 2015 vol. 2015 p. 1 - 8

2314-7156

Tuberculosis (TB) is a major health problem that requires an appropriate cell immune response (IR) to be controlled. Since regulatory T cells (Tregs) are relevant in the regulation of the IR, we analyzed Tregs variations throughout the course of TB treatment and its relationship with changes in immune-endocrine mediators dealing with disease immunopathology. The cohort was composed of 41 adult patients (HIV negatives), 20 of them completing treatment and follow-up. Patients were bled at diagnosis (T0) and at 2 (T2), 4 (T4), 6 (T6) and 9 months following treatment initiation. Twenty four age- and sex-matched healthy controls (HCo) were also included. Plasma cytokines were assessed by ELISA; Cortisol and Dehydroepiandrosterone sulfate (DHEA-S) by electrochemiluminescence and Tregs frequency by flow cytometry. Tregs from TB patients were increased at T0 (vs. HCo p