INVESTIGADORES
RISK Marcelo Raul
artículos
Título:
Control in an Animal Model of Acute Heart Failure Induced by High Dose of Halothane
Autor/es:
JUAN MANUEL CAMUS; AGUSTÍN RAMIREZ; MARCELO RISK; PABLO PALACIOS; EDUARDO DE FORTEZA; EDMUNDO I. CABRERA FISCHER
Revista:
Cardiovascular Engineering and Technology
Editorial:
Springer
Referencias:
Lugar: Amsterdam; Año: 2012 vol. 3 p. 345 - 350
ISSN:
1869-408X
Resumen:
Acute animal models of cardiac failure are neces-
sary to study new therapeutic options and should be thor-
oughly characterized from the hemodynamic point of view,
including the response of the autonomic nervous system.
Thus, the aim of this work was to characterize the patho-
physiological adaptation of the autonomic nervous system to
acute cardiac failure induced by high doses of halothane (4%).
In six sheep, electrocardiogram, aortic pressure and flow were
obtained and calculation of systemic vascular resistances was
done. Variability analyses in the time and frequency domains
were also performed. In the time domain, after heart failure
induction using halothane 4%, a significant decrease of both
aortic blood flow variability (from 0.13 ± 0.05 to 0.09 ±
0.02 L minÀ1, p < 0.05) and the broad band spectra (from
1.80 ± 0.66 to 1.25 ± 0.57 L2 minÀ2, p < 0.005) was observed.
Both mean RR (472 ± 44 to 567 ± 68 ms, p < 0.01), and low
frequency band of RR intervals (from 6.2 ± 0.9 to 7.7 ±
1.5 ms2, p < 0.05), showed a significant increase, and no
change in systemic vascular resistance (from 54.9 ± 29.5 to
50.3 ± 38.4 mmHg min LÀ1), all of them after heart failure
induction. We conclude that in this model of heart failure the
autonomic nervous system activity is still functioning, the
combination of increased mean and RR low frequency band,
with no change in systemic vascular resistance suggest an
increase in the sympathetic control (due to maintained SVR),
in an attempt to compensate the depression in the cardiac
activity and hemodynamic alterations after severe myocardial
depression induced by halothane.