First generation newkome-type dendrimer as solubility enhancer of antitumor benzimidazole carbamate

NAHIR DIB; LUCIANA FERNANDEZ; LUIS OTERO; MARISA SANTO; MARCELO CALDERON; MARISA MARTINELLI; MIRIAM STRUMIA

J Incl Phenom Macrocycl Chem

SPRINGER

Año: 2015 vol. 82 p. 351 - 359

1388-3127

A first generation dendrimer was evaluated assolubility enhancer of the antitumor compound methyl (5-[propylthio]-1H-benzimidazol-2-yl) carbamate. The dendrimer possess carboxylic acid as terminal groups, which provide high water solubility and a low cytotoxic character.The drug-dendrimer association significantly increases active compound solubility in water, avoiding aggregation.The formulation is stable several weeks in a wide temperature range. The formation of Langmuir monolayers in air?water interface of dendrimer-active compound blendsevidences the viability of the complex to generate films for surface-mediated drug delivery systems.