INVESTIGADORES
STRUMIA Miriam Cristina
artículos
Título:
Nanomodification of chitosan microspheres with dendron molecules.
Autor/es:
AGUSTINA ALDANA; MIRIAM STRUMIA; MARISA MARTINELLI
Revista:
Journal of Biomaterials and Tissue Engineering
Editorial:
ASP
Referencias:
Lugar: California; Año: 2013 vol. 3 p. 157 - 163
ISSN:
2157-9083
Resumen:
The importance of dendritic structures in biology and medicine lies in their multivalency. Dendrons
represent a structural component of the parent dendrimer; they have nano-dimensions and
their immobilization on surfaces would lead to structural features within this dimensional range.
Novel dendronized surface of chitosan microspheres was prepared by reaction between crosslinked
biopolymer and Behera?s or bis Behera?s amine dendrons. According to FTIR analysis, it can
be concluded that the dendronization took place; the shape and size were homogeneous and
independent of the dendronization, according SEM images. Interactions between dendron-polymer
network and hydrophilic/hydrophobic characteristics of the dendron modify the physical properties
of the microspheres. The swelling studies of dendronized films at pH 1.2 and 7.4 evidenced the
so-called ?dendritic effect.? In addition, the microspheres remained stable for an extended period.
The highlights of the present research were to develop nanostructured dendronized surfaces on
spheres of polymer supports that seem to be appropriate for biomedical applications. The work
aimed at studying the effect of dendronization of the surface on the original properties of chitosan
microspheres.
Keywords: Dendronized Polymer, Nanostructured Surface, Chitosan, Biomaterials