- Synthesis of Macroporous Polymer Rods Based on an Acrylamide Derivative Monomer.

DARÍO ARRUA, DANIEL SERRANO, GUSTAVO PASTRANA, MIRIAM STRUMIA AND CECILIA ALVAREZ.

Journal Polymer Science. Part A: Polymer Chemistry

Wiley

Lugar: USA; Año: 2006 vol. 44 p. 6616 - 6623

ABSTRACT: New macroporous polymer rods were prepared by free-radical crosslinking copolymerization from N-acryloyl-tris(hydroxymethyl)aminomethane and N,N0- methylenebisacrylamide as a crosslinking agent with different porogenic mixtures and with azobisisobutyronitrile as an initiator. The porous properties of these materials were controlled through changes in the proportions of the porogenic mixture, the polymerization temperature, or the concentration of the crosslinking agent. Pore size distribution profiles that shifted toward a larger pore size were obtained in the following cases: when the percentage of the coporogen was increased, when the copolymerization reactions were carried out at a low temperature (55 8C), and when the crosslinking concentration was reduced. Alternatively, a porogenic mixture formed from dimethyl sulfoxide and a 1:1 combination of tetradecanol and poly(ethylene glycol) 6000 as coporogens yielded a polymer rod with a high porosity and pore size. These hydrophilic materials are promising as base supports for different chromatographic processes and as throughput bioreactors. VVC 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 6616–6623, 2006New macroporous polymer rods were prepared by free-radical crosslinking copolymerization from N-acryloyl-tris(hydroxymethyl)aminomethane and N,N0- methylenebisacrylamide as a crosslinking agent with different porogenic mixtures and with azobisisobutyronitrile as an initiator. The porous properties of these materials were controlled through changes in the proportions of the porogenic mixture, the polymerization temperature, or the concentration of the crosslinking agent. Pore size distribution profiles that shifted toward a larger pore size were obtained in the following cases: when the percentage of the coporogen was increased, when the copolymerization reactions were carried out at a low temperature (55 8C), and when the crosslinking concentration was reduced. Alternatively, a porogenic mixture formed from dimethyl sulfoxide and a 1:1 combination of tetradecanol and poly(ethylene glycol) 6000 as coporogens yielded a polymer rod with a high porosity and pore size. These hydrophilic materials are promising as base supports for different chromatographic processes and as throughput bioreactors. VVC 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 6616–6623, 2006N-acryloyl-tris(hydroxymethyl)aminomethane and N,N0- methylenebisacrylamide as a crosslinking agent with different porogenic mixtures and with azobisisobutyronitrile as an initiator. The porous properties of these materials were controlled through changes in the proportions of the porogenic mixture, the polymerization temperature, or the concentration of the crosslinking agent. Pore size distribution profiles that shifted toward a larger pore size were obtained in the following cases: when the percentage of the coporogen was increased, when the copolymerization reactions were carried out at a low temperature (55 8C), and when the crosslinking concentration was reduced. Alternatively, a porogenic mixture formed from dimethyl sulfoxide and a 1:1 combination of tetradecanol and poly(ethylene glycol) 6000 as coporogens yielded a polymer rod with a high porosity and pore size. These hydrophilic materials are promising as base supports for different chromatographic processes and as throughput bioreactors. VVC 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 6616–6623, 20068C), and when the crosslinking concentration was reduced. Alternatively, a porogenic mixture formed from dimethyl sulfoxide and a 1:1 combination of tetradecanol and poly(ethylene glycol) 6000 as coporogens yielded a polymer rod with a high porosity and pore size. These hydrophilic materials are promising as base supports for different chromatographic processes and as throughput bioreactors. VVC 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 6616–6623, 2006VVC 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 6616–6623, 2006 Keywords: macroporous monoliths; macroporous polymers; matrix; N-acryloyltris(macroporous monoliths; macroporous polymers; matrix; N-acryloyltris(