Regulatory and Mechanistic Actions of Glucocorticoids on T and Inflammatory Cells

STEININGER, A; BUDZIÑSKY, M.L.; ARZT, E.; GOBBINI, R.; STEININGER, A; SOKN, C.; LIBERMAN, A.C.; BUDZIÑSKY, M.L.; ARZT, E.; GOBBINI, R.; SOKN, C.; LIBERMAN, A.C.

Front Endocrinol (Lausanne)

Frontiers Media S.A

Año: 2018 vol. 9

1664-2392

Glucocorticoids (GCs) play an important role in regulating the inflammatory and immune response and have been used since decades to treat various inflammatory and autoimmune disorders. Fine-tuning the glucocorticoid receptor (GR) activity is instrumental in the search for novel therapeutic strategies aimed to reduce pathological signaling and restoring homeostasis. Despite the primary anti-inflammatory actions of GCs, there are studies suggesting that under certain conditions GCs may also exert pro-inflammatory responses. For these reasons the understanding of the GR basic mechanisms of action on different immune cells in the periphery (e.g., macrophages, dendritic cells, neutrophils, and T cells) and in the brain (microglia) contexts, that we review in this chapter, is a continuous matter of interest and may reveal novel therapeutic targets for the treatment of immune and inflammatory response.