IBIOBA - MPSP 22718
INSTITUTO DE INVESTIGACION EN BIOMEDICINA DE BUENOS AIRES - INSTITUTO PARTNER DE LA SOCIEDAD MAX PLANCK
Unidad Ejecutora - UE
artículos
Título:
CRH acts anxiolytic by modulating dopamine release through a subset of GABAergic long-range projection neurons
Autor/es:
WURST W,; GRINEVICH V,; ALMADA R, ; VOGL AM,; POEHLMANN M,; GENEWSKY A; KUEHNE C,; DEUSSING JM,; SCHMIDT M; WOTJAK CT,; SCHMIDT M; KOLARZ A,; ANDERSHANOVA E; HARTMANN J,; REFOJO D,; DEDIC N,; CHEN A; RESSLER KJ,; METZGER MW; CHANG S,; GOMES KS; JAKOVCEVSKI M,
Revista:
NATURE NEUROSCIENCE.
Editorial:
NATURE PUBLISHING GROUP
Referencias:
Lugar: Londres; Año: 2018 vol. 21 p. 803 - 807
ISSN:
1097-6256
Resumen:
The interplay between corticotropin-releasing hormone (CRH)and the dopaminergic system has predominantly been studiedin addiction and reward, while CRH?dopamine interactions inanxiety are scarcely understood. We describe a new populationof CRH-expressing, GABAergic, long-range-projectingneurons in the extended amygdala that innervate the ventraltegmental area and alter anxiety following chronic CRH depletion.These neurons are part of a distinct CRH circuit that actsanxiolytically by positively modulating dopamine release.
