Evidence of impaired microglial autophagy in Alzheimer?s disease: from in vitro models to patients

POMILIO, C.; GOROJOD R; VINUESA A; RIUDAVETS, MIGUEL; PRESA J; GREGOSA, AMAL; BENTIVEGNA M; ALAIMO A; SEVLEVER, GUSTAVO; KOTLER M; BEAUQUIS J; SARAVIA F

Mar del Plata

Congreso; Reunion de la Sociedad Argentina de Investigación Clínica; 2019

SAIC

Alzheimer?s disease (AD) is a neurodegenerative disease, characterized by the presence of extracellular amyloid plaques that are mainly composed by Amyloid-β peptides (Aβ). Microglial activation plays a crucial role in the clearance of Aβ, and other studies suggest that microglial autophagy may also participate in this function. Our aim was to study whether microglial autophagy could be affected during progression of AD, using in vivo and in vitro models. The hippocampus of aged PDAPPJ20 mice ?a validated animal model of AD? showed hyper reactive Iba1+ cells around plaques. Compared with age matched controls, microglia in AD mice lost the lysosomal phagocytic marker CD68 (p