Endothelial and astroglial alterations in in vitro and in vivo models of Alzheimer?s disease. Evidence of cell activation and autophagic induction.

POMILIO C; GOROJOD R; TODERO MF; VINUESA A; ALAIMO A; KOTLER M; BEAUQUIS J; SARAVIA F

Buenos Aires

Congreso; FALAN; 2016

FALAN

Endothelial and astroglial alterations in in vitro and in vivo models of Alzheimer?s disease.Evidence of cell activation and autophagic induction.Pomilio C, Gorojod R, Todero MF, Vinuesa A, Alaimo A, Kotler M, Beauquis J, Saravia FAlzheimer?s disease (AD) is the principal cause of dementia in the elderly. The overproductionof Amyloid-β peptides (Aβ) and their aggregation into senile plaques are recognized hallmarks in AD. Aβ is able to affect neurons and synapsis, but also it activates glial and endothelial cells -components of the neurovascular unit- altering brain homeostasis. In this study, we characterized astroglial and vascular alterations in in vitro conditions and using a mouse model of AD. Before plaque deposition, AD mice exhibited less astrocytes (p