INSULIN RESISTANCE AND GLIAL ACTIVATION AS CONCURRENT EVENTS IN EXPERIMENTAL ALZHEIMER’S DISEASE.

BENTIVEGNA, MELISA; GREGOSA, AMAL; VINUESA, ANGELES; POMILIO, CARLOS; BELLOTTO, MELINA; BONAVENTURA, MARÍA MARTA; PRESA, JESSICA; PÉREZ, NICOLÁS GONZÁLEZ; VICTORIA LUX-LANTOS; FLAVIA EUGENIA SARAVIA; BEAUQUIS JUAN

Mar del Plata

Congreso; Reunion Anual de la Sociedad Argentina de Investigacion Clinica; 2023

SAIC

Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease and the leading cause ofdementia. Besides amyloid beta (AB) and tau accumulation, inflammation and insulin resistance arecommon findings in AD brains. Astrocytes regulate these processes maintaining brain homeostasis andcoordinating the inflammatory response.In the present work, our objectives were 1) to study the metabolic and inflammatory status of the PDAPPJ20 transgenic (TG) mouse, model of AD, and 2) to evaluate astroglial activation and insulin signaling uponAB exposure. We hypothesized that in AD, astrocytes adopt a phenotype that promotes inflammation andlose homeostatic functions.Evaluation in the open-field test showed an anxious-like behavior in TG mice. Insulin signaling measuredby the pAkt/Akt ratio was impaired in the hippocampus (p