DIETARY RESTRICTION AS A FASTING MIMETIC IN AGED MICE. METABOLIC, COGNITIVE, AND NEUROINFLAMMATORY EVALUATION.

GREGOSA, AMAL; BENTIVEGNA, MELISA; VINUESA A; POMILIO C; PRESA, JESSICA; FLAVIA EUGENIA SARAVIA; BEAUQUIS JUAN

Congreso; Reunion Anual de la Sociedad Argentina de Investigacion Clinica; 2021

SAIC

Aging is a physiological process that involves cognitive decline,decreased autophagic flux, and increased oxidative stress. Dietaryrestriction is a multitarget strategy that has been linked to severalbenefits, inducing autophagy flux, decreasing oxidative stress andinflammation, and improving metabolism. These effects establish dietaryrestriction as a possible approach to delay physiological agingand to prevent or treat aging-related diseases. In a previous work,we evaluated a protocol of periodic dietary restriction (PDR) in ananimal model of familial Alzheimer’s disease. Now, we have studiedthe effects of this strategy on aged female mice (16 month-old),evaluating metabolic, cognitive, and neuroinflammatory changes.PDR involved 5 days of dietary restriction (DR) alternated with 9days of ad libitum (AL) food intake for 7 weeks. During the DR period,mice ate 60% of their habitual intake.Animals under PDR showed similar body weight and glycemia toAL mice. During DR periods, circulating ketone bodies increased(1WAnova-Sidak, basal vs DR p