INVESTIGADORES
SARAVIA Flavia Eugenia
artículos
Título:
Brain alterations in diabetes mellitus: focus on HPA axis disturbances
Autor/es:
BEAUQUIS J, HOMO-DELARCHE F, DE NICOLA AF, SARAVIA F.
Revista:
NEUROIMMUNOMODULATION.
Referencias:
Año: 2008 vol. 15 p. 61 - 67
ISSN:
1021-7401
Resumen:
Type 1 diabetes (T1D) is linked to an encephalopathy explained
by some features common to the aging process, degenerative
and functional disorders of the central nervous
system. In the present study we describe a manifest hyperactivity
of the hypothalamic-pituitary-adrenal (HPA) axis in two
different experimental mouse models of T1D including the
pharmacological one induced by streptozotocin and the
spontaneous NOD (nonobese diabetic mice). The high expression
of hypothalamic hormones like oxytocin and vasopressin
were part to this alteration, together with elevated
adrenal glucocorticoids and prominent susceptibility to
stress. In the hippocampus of diabetic animals a marked astrogliosis,
often associated with neural damage, was present.
Dentate gyrus neurogenesis was also affected by the disease:
proliferation and differentiation measured by bromodeoxyuridine
immunodetection were significantly reduced in both
experimental models used.