Bioproduction of floxuridine using nanostabilized biocatalysts

CAPPA VALERIA; RIVERO CINTIA; JORGE SAMBETH; TRELLES JORGE

Chemical Engineering & Technology

WILEY-VCH Verlag GmbH & Co

Lugar: Weinheim; Año: 2016 vol. 39 p. 1723 - 1730

Bionanocomposites employing natural polysaccharides such as alginate and nanoclays such as bentonite are a promising alternative to developing stabilized biocatalysts used in the pharmaceutical industry due to their physicochemical properties, biocompatibility and nontoxicity. In this work, mechanical parameters such as swelling ratio, compressive strength and fracture frequency were optimized, favoring scale-up. Moreover, storage stability and reusability of the biocatalysts were improved by more than 90% compared with control conditions. In addition, immobilized lactic acid bacteria were used in the bioprocess scale-up to obtain floxuridine, showing a productivity of 596 mg per gram of biocatalyst.