INVESTIGADORES
SALOMON Claudio Javier
artículos
Título:
Efficacy of novel benznidazole solutions in experimental infection with Trypanosoma cruzi
Autor/es:
MARÍA C. LAMAS; EMANUEL BOTTASSO; ESTEBAN SERRA; SILVIA REVELLI; CLAUDIO SALOMON
Revista:
PARASITOLOGY INTERNATIONAL
Editorial:
ELSEVIER IRELAND LTD
Referencias:
Lugar: Amsterdam; Año: 2012 vol. 62 p. 79 - 81
ISSN:
1383-5769
Resumen:
Chagas' disease is caused by the protozoan parasite Trypanosoma cruzi. About 8 million people throughout Latin
America are infected causing approximately 10,000 deaths annually. Benznidazole, available as unique 100 mg
tablets in many of the endemic countries, is currently the drug of choice for the specific treatment of this condition.
Despite of the large number of pediatric patients infected, there are no commercial liquid dosage forms
available to treat this trypanosomiasis. This work showed that novel benznidazole?water?polyethylene glycol
400 solutions are active against T. cruzi in a murine model of Chagas' disease. Present results constitute the
first demonstration on the usefulness of benznidazole solutions in infected mice.