Solvent and catalysis-free microware transesterification of β-ketoesters ant its application in the production of potential antitumor dihydropyrimidinones (thiones)-fatty acids derivatives

EDNA XIMENA AGUILERA; LICK, ILEANA D.; BARBELLI LAURA; CASELLA, MÓNICA L; M. MURGUIA; LUIS R PIZZIO; GUSTAVO P. ROMANELLI

Tunja

Jornada; Primeras jornadas del Grupo de Catálisis de la Universidad Pedagógica y Tecnológica de Colombia; 2022

Universidad Pedagógica y Tecnológica de Colombia

In this work we report a study of the transesterification reaction of β-ketoesters in solvent-free conditions and in the absence of a catalyst, using microwave radiation. Different alcohols including fatty alcohols were tested in order to optimize the reaction conditions. Good yields, without the formation of secondary products, were observed at 130 °C, in periods of time that did not exceed 3 h, using microwave irradiation. The compounds obtained were used as starting substrates in a Biginelli-type multicomponent synthesis to obtain 3,4-dihydropyrimidin-2(1H)-ones (thiones) C-5 long chain ester derivatives, at 80 °C in solvent-free condition using bulk tungstophosphoric as catalyst. Several DHP-derivatives were obtained in about 4 h, with a yield greater than 50%.