INVESTIGADORES
PIZZIO Luis Rene
artículos
Título:
An Efficient and Green Catalytic Method for Friedländer Quinoline Synthesis Using Tungstophosphoric Acid Included in a Polymeric Matrix
Autor/es:
DANIEL BENNARDI; MIRTA N. BLANCO.,; LUIS RENÉ PIZZIO; JUAN CARLOS AUTINO; GUSTAVO P. ROMANELLI
Revista:
Current Catalysis
Editorial:
Bentham Science
Referencias:
Lugar: Oak Park; Año: 2015 vol. 4 p. 65 - 72
ISSN:
2211-5447
Resumen:
A new, efficient and green methodology for obtaining quinolines based on the useof tungstophosphoric acid included in a polymeric matrix of polyacrylamide is proposed(APTPOL60). The methodology involves the formation of polysubstituted quinoline compoundsusing a variety of 2-aminoaryl ketones and -dicarbonyl compounds, in absolute ethanol as reaction solvent,and a temperature of 78 ºC. The catalyst efficiency is not compromised after its successive use in reactions,and no leaching was observed. Seven examples of quinolone derivatives were obtained with excellent yields(89%-99%). This is the first report about the use of a heteropolyacid included in a polymeric matrix as recyclablecatalyst in the Friedländer synthesis of quinoline derivatives (molecules with biological activity potential).
