Microbial transformation of S-(-)-Perillyl Alcohol by the filamentous fungi Fusarium verticillioides.

ACIAR, ROXANA M. A.; RAVETTI, SOLEDAD; ALLENDES, JORGE; ROSA, MELISA; HERGERT, LISANDRO Y.; BUSTOS, PAMELA S.; ORTEGA, MARÍA G.; PARAJE, MARÍA G; BUSTOS, DANIEL A.

JOURNAL OF BIOTECHNOLOGY

ELSEVIER SCIENCE BV

Lugar: Amsterdam; Año: 2013

0168-1656

S-(-)-Perillyl alcohol (1) was transformed by Fusarium verticilloides over 7 days at 25°C to S-(-)-Perillyl aldehyde (2). Its structure was established by NMR spectroscopic and mass spectral studies. Total antioxidant potential and the radical-scavenging activity were determined by phosphomolybdenum and ABTS?+ assays, respectively. The results demonstrated that the oxidation of the primary alcohol of 1 had no effect on antioxidant activity when compared to starting material and a reference compound. Obtaining derivatives of 1, is an important goal of research in microbial biotechnology and medicinal chemistry.