INVESTIGADORES
PALMA Santiago Daniel
congresos y reuniones científicas
Título:
Cinética comparativa de tres diferentes formulaciones de albendazole sulfóxido luego de la administración oral en caninos
Autor/es:
DIB A; PALMA, SANTIAGO; SUAREZ G; FARIAS C; CABRERA A; CASTRO, SILVINA; ALLEMANDI, DANIEL; MORENO L; SANCHEZ BRUNI S; LANUSSE CARLOS
Lugar:
Tandil, Buenos Aires.
Reunión:
Congreso; Sociedad Argentina de Farmacologia Experimental. SAFE 2008; 2008
Institución organizadora:
SAFE - Sociedad Argentina de Farmacologia experimental
Resumen:
New therapeutics alternatives using Benzimidazole compounds are being studied to improve posology and antiparasite efficacy. The aim of this work was to compare plasma pharmacokinetics (PK) profiles of three different oral Albendazole (ABZ)-based formulations in dogs. Nine animals were randomly divided into three groups and two phases (incomplete block design). Phase I (n=9): Group I (formulation A): received 25 mg/kg of ABZ conventionally formulated. Group II (formulation B) received 25mg/kg of a modified ABZ formulation (poloxamer solid dispersion)). Group III (Formulation C), received Albendazole Sulfoxide (ABZSO) (equimolar dose). After 21 days of wash-out period the experiment was repeatead as Phase II. Blood samples were taken over 24h and subsequently analyzed by HPLC. ABZSO and ABZSO2 were the analytes recovered in plasma. Significant (P<0.001) AUC values (+500%) and Cmax (+487%) for ABZSO, were obtained for the formulation C when statiscallycompared with A and B. However, no statistical differences on PK parameters were found between A and B formulations. In conclusion formulation C, showed the best trend as potentialantiparasite activity.