Cross-linking modification of hyaluronanitaconic acid films to prepare platforms with potential application to drug delivery systems

CALLES JAVIER; LOPEZ GARCIA; PALMA, SANTIAGO; VALLES ENRIQUE; DIEBOLD YOLANDA

Congreso; Modest Praga 2012; 2012

Introduction: Traditional dosage forms (solutions, suspensions and ointments) are limited in solving a lot of eye diseases mainly due to the rapid and extensive loss of the formulation of precorneal area under drainage, blinking and tear replacement. The hyaluronic acid sodium salt, also known as hyaluronan (HA), is a naturally occurring, high molecular mass linear biopolymer. It is a promising biomaterial to design modified drug delivery systems (DDS) in ophthalmic applications. Due to HA low stability in living tissues, some chemical modifications are necessary to obtain stable films that are appropriate to be used as DDS in ophthalmic applications. In this work we explore crosslinking formulations for HA using polyethylene glycol diglycidyl ether (PEGDE) in the presence of itaconic acid (IT) to obtain hidrogels appropriate to prepare films with good bioadhesive and mechanical properties as potential DDS.