Cytokines and Chemokines Shaping B cell Compartment.

ACOSTA E,; MERINO, MC; MONTES, CAROLINA L; MOTRAN, CLAUDIA CRISTINA; GRUPPI, ADRIANA

CYTOKINE & GROWTH FACTOR REVIEWS

ELSEVIER SCI LTD

Lugar: Amsterdam; Año: 2007 p. 73 - 83

1359-6101

The whole life of a B-cell from a stem cell to a mature plasma cell is governed, among other factors, by cytokines and growth factors in their microenvironment. Remarkable progress in the understanding of the mechanisms of cytokines action on the B-cell compartment was achieved by analysis of gene-targeted mice. The generation of mice deficient for individual cytokines or their receptors has shed light on the in vivo function of cytokines in B-cell responses. This review focuses on the role of cytokines in the development, maturation and differentiation of different B-cell subsets into antibody-secreting cells or memory B-cells.