The role of pregnancy-specific glycoprotein 1a (PSG1a) in regulating the innate and adaptive immune response.

MARTINEZ, FERNANDO; CERVI, LAP; KNUBEL, C; PANZETTA-DUTARI, G; MOTRAN, CLAUDIA C

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

WILEY-BLACKWELL PUBLISHING, INC

Lugar: Londres; Año: 2013 vol. 64 p. 383 - 394

1046-7408

Among several explanations for the acceptance of the fetus, the one that suggests that the maternal immune system is suppressed or modified has been the subject of many studies. Thus, it has been proposed that the cells of innate immune system might be able to distinguish the preg-nant from the non-pregnant state producing a signal, the so-called signal P. We have previously proposed that pregnancy-specific glycopro-tein 1a (PSG1a), a representative member of the main glycoprotein fam-ily secreted by placental trophoblast, may modulate the activation of antigen-presenting cells promoting the T-cell shift of the maternal cell immunity toward a less harmful phenotype. In this review, we summa-rize current knowledge concerning the contribution of pregnancy-specific glycoprotein 1a (PSG1a) to modulate the maternal innate and adaptive immune response in order to assure a successful pregnancy.