INVESTIGADORES
MOTRAN Claudia Cristina
artículos
Título:
Helminth Antigens Enable CpG-Activated Dendritic Cells
Autor/es:
CARRANZA, F; FALCON, C; NUNEZ, NICOLAS; KNUBEL, C; CORREA, S; BIANCO, I; MACCIONI, M; FRETES, R; TRIQUEL, MF; MOTRAN, CLAUDIA C; CERVI, LAP
Revista:
PLOS ONE
Editorial:
PUBLIC LIBRARY SCIENCE
Referencias:
Lugar: San Francisco; Año: 2012 vol. 7 p. 40356 - 40365
ISSN:
1932-6203
Resumen:
Dendritic cells (DC) have the potential to control the outcome of autoimmunity by modulating the immune response. In this
study, we tested the ability of Fasciola hepatica total extract (TE) to induce tolerogenic properties in CpG-ODN (CpG)
maturated DC, to then evaluate the therapeutic potential of these cells to diminish the inflammatory response in collagen
induced arthritis (CIA). DBA/1J mice were injected with TE plus CpG treated DC (T/C-DC) pulsed with bovine collagen II (CII)
between two immunizations with CII and clinical scores CIA were determined. The levels of CII-specific IgG2 and IgG1 in
sera, the histological analyses in the joints, the cytokine profile in the draining lymph node (DLN) cells and in the joints, and
the number, and functionality of CD4+CD25+Foxp3+ T cells (Treg) were evaluated. Vaccination of mice with CII pulsed T/CDC
diminished the severity and incidence of CIA symptoms and the production of the inflammatory cytokine, while induced
the production of anti-inflammatory cytokines. The therapeutic effect was mediated by Treg cells, since the adoptive
transfer of CD4+CD25+ T cells, inhibited the inflammatory symptoms in CIA. The in vitro blockage of TGF-b in cultures of
DLN cells plus CII pulsed T/C-DC inhibited the expansion of Treg cells. Vaccination with CII pulsed T/C-DC seems to be a very
efficient approach to diminish exacerbated immune response in CIA, by inducing the development of Treg cells, and it is
therefore an interesting candidate for a cell-based therapy for rheumatoid arthritis (RA).
DLN cells plus CII pulsed T/C-DC inhibited the expansion of Treg cells. Vaccination with CII pulsed T/C-DC seems to be a very
efficient approach to diminish exacerbated immune response in CIA, by inducing the development of Treg cells, and it is
therefore an interesting candidate for a cell-based therapy for rheumatoid arthritis (RA).
DLN cells plus CII pulsed T/C-DC inhibited the expansion of Treg cells. Vaccination with CII pulsed T/C-DC seems to be a very
efficient approach to diminish exacerbated immune response in CIA, by inducing the development of Treg cells, and it is
therefore an interesting candidate for a cell-based therapy for rheumatoid arthritis (RA).
DLN cells plus CII pulsed T/C-DC inhibited the expansion of Treg cells. Vaccination with CII pulsed T/C-DC seems to be a very
efficient approach to diminish exacerbated immune response in CIA, by inducing the development of Treg cells, and it is
therefore an interesting candidate for a cell-based therapy for rheumatoid arthritis (RA).
diminished the severity and incidence of CIA symptoms and the production of the inflammatory cytokine, while induced
the production of anti-inflammatory cytokines. The therapeutic effect was mediated by Treg cells, since the adoptive
transfer of CD4+CD25+ T cells, inhibited the inflammatory symptoms in CIA. The in vitro blockage of TGF-b in cultures of
DLN cells plus CII pulsed T/C-DC inhibited the expansion of Treg cells. Vaccination with CII pulsed T/C-DC seems to be a very
efficient approach to diminish exacerbated immune response in CIA, by inducing the development of Treg cells, and it is
therefore an interesting candidate for a cell-based therapy for rheumatoid arthritis (RA).
DLN cells plus CII pulsed T/C-DC inhibited the expansion of Treg cells. Vaccination with CII pulsed T/C-DC seems to be a very
efficient approach to diminish exacerbated immune response in CIA, by inducing the development of Treg cells, and it is
therefore an interesting candidate for a cell-based therapy for rheumatoid arthritis (RA).
DLN cells plus CII pulsed T/C-DC inhibited the expansion of Treg cells. Vaccination with CII pulsed T/C-DC seems to be a very
efficient approach to diminish exacerbated immune response in CIA, by inducing the development of Treg cells, and it is
therefore an interesting candidate for a cell-based therapy for rheumatoid arthritis (RA).
DLN cells plus CII pulsed T/C-DC inhibited the expansion of Treg cells. Vaccination with CII pulsed T/C-DC seems to be a very
efficient approach to diminish exacerbated immune response in CIA, by inducing the development of Treg cells, and it is
therefore an interesting candidate for a cell-based therapy for rheumatoid arthritis (RA).
diminished the severity and incidence of CIA symptoms and the production of the inflammatory cytokine, while induced
the production of anti-inflammatory cytokines. The therapeutic effect was mediated by Treg cells, since the adoptive
transfer of CD4+CD25+ T cells, inhibited the inflammatory symptoms in CIA. The in vitro blockage of TGF-b in cultures of
DLN cells plus CII pulsed T/C-DC inhibited the expansion of Treg cells. Vaccination with CII pulsed T/C-DC seems to be a very
efficient approach to diminish exacerbated immune response in CIA, by inducing the development of Treg cells, and it is
therefore an interesting candidate for a cell-based therapy for rheumatoid arthritis (RA).
DLN cells plus CII pulsed T/C-DC inhibited the expansion of Treg cells. Vaccination with CII pulsed T/C-DC seems to be a very
efficient approach to diminish exacerbated immune response in CIA, by inducing the development of Treg cells, and it is
therefore an interesting candidate for a cell-based therapy for rheumatoid arthritis (RA).
DLN cells plus CII pulsed T/C-DC inhibited the expansion of Treg cells. Vaccination with CII pulsed T/C-DC seems to be a very
efficient approach to diminish exacerbated immune response in CIA, by inducing the development of Treg cells, and it is
therefore an interesting candidate for a cell-based therapy for rheumatoid arthritis (RA).
DLN cells plus CII pulsed T/C-DC inhibited the expansion of Treg cells. Vaccination with CII pulsed T/C-DC seems to be a very
efficient approach to diminish exacerbated immune response in CIA, by inducing the development of Treg cells, and it is
therefore an interesting candidate for a cell-based therapy for rheumatoid arthritis (RA).
diminished the severity and incidence of CIA symptoms and the production of the inflammatory cytokine, while induced
the production of anti-inflammatory cytokines. The therapeutic effect was mediated by Treg cells, since the adoptive
transfer of CD4+CD25+ T cells, inhibited the inflammatory symptoms in CIA. The in vitro blockage of TGF-b in cultures of
DLN cells plus CII pulsed T/C-DC inhibited the expansion of Treg cells. Vaccination with CII pulsed T/C-DC seems to be a very
efficient approach to diminish exacerbated immune response in CIA, by inducing the development of Treg cells, and it is
therefore an interesting candidate for a cell-based therapy for rheumatoid arthritis (RA).
DLN cells plus CII pulsed T/C-DC inhibited the expansion of Treg cells. Vaccination with CII pulsed T/C-DC seems to be a very
efficient approach to diminish exacerbated immune response in CIA, by inducing the development of Treg cells, and it is
therefore an interesting candidate for a cell-based therapy for rheumatoid arthritis (RA).
DLN cells plus CII pulsed T/C-DC inhibited the expansion of Treg cells. Vaccination with CII pulsed T/C-DC seems to be a very
efficient approach to diminish exacerbated immune response in CIA, by inducing the development of Treg cells, and it is
therefore an interesting candidate for a cell-based therapy for rheumatoid arthritis (RA).
DLN cells plus CII pulsed T/C-DC inhibited the expansion of Treg cells. Vaccination with CII pulsed T/C-DC seems to be a very
efficient approach to diminish exacerbated immune response in CIA, by inducing the development of Treg cells, and it is
therefore an interesting candidate for a cell-based therapy for rheumatoid arthritis (RA).
+CD25+Foxp3+ T cells (Treg) were evaluated. Vaccination of mice with CII pulsed T/CDC
diminished the severity and incidence of CIA symptoms and the production of the inflammatory cytokine, while induced
the production of anti-inflammatory cytokines. The therapeutic effect was mediated by Treg cells, since the adoptive
transfer of CD4+CD25+ T cells, inhibited the inflammatory symptoms in CIA. The in vitro blockage of TGF-b in cultures of
DLN cells plus CII pulsed T/C-DC inhibited the expansion of Treg cells. Vaccination with CII pulsed T/C-DC seems to be a very
efficient approach to diminish exacerbated immune response in CIA, by inducing the development of Treg cells, and it is
therefore an interesting candidate for a cell-based therapy for rheumatoid arthritis (RA).
DLN cells plus CII pulsed T/C-DC inhibited the expansion of Treg cells. Vaccination with CII pulsed T/C-DC seems to be a very
efficient approach to diminish exacerbated immune response in CIA, by inducing the development of Treg cells, and it is
therefore an interesting candidate for a cell-based therapy for rheumatoid arthritis (RA).
DLN cells plus CII pulsed T/C-DC inhibited the expansion of Treg cells. Vaccination with CII pulsed T/C-DC seems to be a very
efficient approach to diminish exacerbated immune response in CIA, by inducing the development of Treg cells, and it is
therefore an interesting candidate for a cell-based therapy for rheumatoid arthritis (RA).
DLN cells plus CII pulsed T/C-DC inhibited the expansion of Treg cells. Vaccination with CII pulsed T/C-DC seems to be a very
efficient approach to diminish exacerbated immune response in CIA, by inducing the development of Treg cells, and it is
therefore an interesting candidate for a cell-based therapy for rheumatoid arthritis (RA).
+CD25+ T cells, inhibited the inflammatory symptoms in CIA. The in vitro blockage of TGF-b in cultures of
DLN cells plus CII pulsed T/C-DC inhibited the expansion of Treg cells. Vaccination with CII pulsed T/C-DC seems to be a very
efficient approach to diminish exacerbated immune response in CIA, by inducing the development of Treg cells, and it is
therefore an interesting candidate for a cell-based therapy for rheumatoid arthritis (RA).