Advanced SSNMR tecniques, FTIR and XRD applied to polymorphism in a pharmaceutical compound

Y. GARRO LINCK; A. K. CHATTAH; C. B. ROMAÑUK; M. E. OLIVERA; R. H. MANZO; M. T. GARLAND; S CUFFINI; G. A. MONTI

Angra do Reis, Brasil

Congreso; 12th NMR Users Meeting and 3rd Iberoamerican NMR Meeting; 2009

AUREM

Polymorphism has been recognized as an important element of drug development.1 The fluoroquinolone (FQ) Ciprofloxacin (CIP) is a widely prescribed broad-spectrum oral antibiotic. Saccharin (SAC) is one of the best known and most widely used artificial sweetening agents.  Also, it has been proposed that it could be used to improve organoleptic properties of drugs. New pharmaceutical derivatives of fluoroquinolones with SAC having sweet taste, have been recently reported.2 In the present work we characterize the CIP-SAC form II, which is compared with the previously reported form (I).2 CIP-SAC (II) was successfully obtained as a single-crystal.