INVESTIGADORES
MONTI Gustavo Alberto
artículos
Título:
Multinuclear solid state NMR investigation of two polymorphic forms of Ciprofloxacin-saccharinate
Autor/es:
Y. GARRO LINCK; A. K. CHATTAH; R. GRAF; C. B. ROMAÑUK; M. E. OLIVERA; R. H. MANZO; G. A. MONTI; H. W. SPIESS
Revista:
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
Editorial:
ROYAL SOC CHEMISTRY
Referencias:
Año: 2011 vol. 13 p. 6590 - 6596
ISSN:
1463-9076
Resumen:
Two polymorphic forms of a novel pharmaceutical compound, ciprofloxacin-saccharinate
(CIP-SAC), are analyzed using one dimensional (1D) and two dimensional (2D) 1H nuclear
magnetic resonance (NMR) at fast magic angle spinning (MAS). Additionally 15N spectroscopy
and 1H13C correlation experiments were performed to complement our conclusions. The
1D 1H NMR spectra of CIP and complexes reveal valuable information about the ionic bonding
between ciprofloxacin and saccharine. Additionally, these spectra allow us to perform a clear
characterization of each solid form, giving the number of molecules per unit cell in one of the
polymorphs. From 2D 1H1H spectra obtained through double quantum correlations we can
arrive at important conclusions about the hydrogen bonding, conformation, and intra and
inter-molecular interactions present in these compounds. Comparing and contrasting the 1H1H
correlation data obtained for both polymorphic forms and taking into account the single crystal
structure data existing for the solid form CIP-SAC (II) was possible to extract some conclusions
on the polymorph CIP-SAC (I) where no single crystal information is available. 1H MAS NMR
is shown to be an important tool in the field of polymorphism and for the characterization of
multicomponent pharmaceutical compounds.1H nuclear
magnetic resonance (NMR) at fast magic angle spinning (MAS). Additionally 15N spectroscopy
and 1H13C correlation experiments were performed to complement our conclusions. The
1D 1H NMR spectra of CIP and complexes reveal valuable information about the ionic bonding
between ciprofloxacin and saccharine. Additionally, these spectra allow us to perform a clear
characterization of each solid form, giving the number of molecules per unit cell in one of the
polymorphs. From 2D 1H1H spectra obtained through double quantum correlations we can
arrive at important conclusions about the hydrogen bonding, conformation, and intra and
inter-molecular interactions present in these compounds. Comparing and contrasting the 1H1H
correlation data obtained for both polymorphic forms and taking into account the single crystal
structure data existing for the solid form CIP-SAC (II) was possible to extract some conclusions
on the polymorph CIP-SAC (I) where no single crystal information is available. 1H MAS NMR
is shown to be an important tool in the field of polymorphism and for the characterization of
multicomponent pharmaceutical compounds.15N spectroscopy
and 1H13C correlation experiments were performed to complement our conclusions. The
1D 1H NMR spectra of CIP and complexes reveal valuable information about the ionic bonding
between ciprofloxacin and saccharine. Additionally, these spectra allow us to perform a clear
characterization of each solid form, giving the number of molecules per unit cell in one of the
polymorphs. From 2D 1H1H spectra obtained through double quantum correlations we can
arrive at important conclusions about the hydrogen bonding, conformation, and intra and
inter-molecular interactions present in these compounds. Comparing and contrasting the 1H1H
correlation data obtained for both polymorphic forms and taking into account the single crystal
structure data existing for the solid form CIP-SAC (II) was possible to extract some conclusions
on the polymorph CIP-SAC (I) where no single crystal information is available. 1H MAS NMR
is shown to be an important tool in the field of polymorphism and for the characterization of
multicomponent pharmaceutical compounds.1H13C correlation experiments were performed to complement our conclusions. The
1D 1H NMR spectra of CIP and complexes reveal valuable information about the ionic bonding
between ciprofloxacin and saccharine. Additionally, these spectra allow us to perform a clear
characterization of each solid form, giving the number of molecules per unit cell in one of the
polymorphs. From 2D 1H1H spectra obtained through double quantum correlations we can
arrive at important conclusions about the hydrogen bonding, conformation, and intra and
inter-molecular interactions present in these compounds. Comparing and contrasting the 1H1H
correlation data obtained for both polymorphic forms and taking into account the single crystal
structure data existing for the solid form CIP-SAC (II) was possible to extract some conclusions
on the polymorph CIP-SAC (I) where no single crystal information is available. 1H MAS NMR
is shown to be an important tool in the field of polymorphism and for the characterization of
multicomponent pharmaceutical compounds.1H NMR spectra of CIP and complexes reveal valuable information about the ionic bonding
between ciprofloxacin and saccharine. Additionally, these spectra allow us to perform a clear
characterization of each solid form, giving the number of molecules per unit cell in one of the
polymorphs. From 2D 1H1H spectra obtained through double quantum correlations we can
arrive at important conclusions about the hydrogen bonding, conformation, and intra and
inter-molecular interactions present in these compounds. Comparing and contrasting the 1H1H
correlation data obtained for both polymorphic forms and taking into account the single crystal
structure data existing for the solid form CIP-SAC (II) was possible to extract some conclusions
on the polymorph CIP-SAC (I) where no single crystal information is available. 1H MAS NMR
is shown to be an important tool in the field of polymorphism and for the characterization of
multicomponent pharmaceutical compounds.1H1H spectra obtained through double quantum correlations we can
arrive at important conclusions about the hydrogen bonding, conformation, and intra and
inter-molecular interactions present in these compounds. Comparing and contrasting the 1H1H
correlation data obtained for both polymorphic forms and taking into account the single crystal
structure data existing for the solid form CIP-SAC (II) was possible to extract some conclusions
on the polymorph CIP-SAC (I) where no single crystal information is available. 1H MAS NMR
is shown to be an important tool in the field of polymorphism and for the characterization of
multicomponent pharmaceutical compounds.1H1H
correlation data obtained for both polymorphic forms and taking into account the single crystal
structure data existing for the solid form CIP-SAC (II) was possible to extract some conclusions
on the polymorph CIP-SAC (I) where no single crystal information is available. 1H MAS NMR
is shown to be an important tool in the field of polymorphism and for the characterization of
multicomponent pharmaceutical compounds.1H MAS NMR
is shown to be an important tool in the field of polymorphism and for the characterization of
multicomponent pharmaceutical compounds.