CONICET | Buscador de Institutos y Recursos Humanos

Intracellular transport of large cargoes, such as organelles, vesicles, or large proteins, is a complex dynamical process that involves the interplay of ATP-consuming molecular motors, cytoskeleton filaments, and the viscoelastic cytoplasm. Impaired activity of molecular motors is associated with different pathologies such as cardiac hypertrophic diseases, defects in mitosos, meiosis or the localization of synaptic vesicles. We investigate the motion of pigment organelles (melanosomes) driven by molecular motors in Xenopus laevis melanocytes using a high-spatio-temporal resolution tracking technique, which allows recovering individual trajectories of melasonomes inside living cells. By analyzing the obtained trajectories, we show that the melanosomes meansquare displacement undergoes transitions between different anomalous behaviors, which are interpreted by means of a generalized Langevin equation. In this talk I will describe briefly the results obtained from the analysis of the data and their implications in intracellular transport.