Splice Site Recognition and Regulation

MARCELO YANOVSKY; MAXIMILIANO BECKEL; ISERTE JAVIER; ARIEL CHERNOMORETZ; ANDRES RABINOVICH

Congreso; VIII congreso Argentino de Bioinformatica y Biologia Computacional; 2017

Asoc Argentina de Bioinformatica y Biologia Computacional

One of the most important aspects of alternative splicing regulation is therecognition of splice sites. Even though splice sites present a consensussequence, there is a sequence variability that is usually related to site strength,ie. site recognition by Spliceosome[1]. On the other hand splice sites recognition coulddepend on different kind of trans factors. One of them is PRMT5 (Protein arginin metiltransferases5) that methilates several splicing factors among others kind of targets[2].In a recent work[3] suggests that mutation of PRMT5 would affect the recognition of weak 5´ donor splice sites (5ss) triggering global effects on the splicing landscape.What is the effect and the meaning of the splice site sequence variation and how organisms deal with this are important questions that need more effort to be completely understand.