Concentrarion estimates from counting individual molecules

PEREZ IPIÑA EMILIANO; PONCE DAWSON SILVINA

Baltimore

Congreso; Biophysical Society 59th Annual Meeting; 2015

The transmission of information in cells usually involves changes in concentration that need to be read by different cell components. Very often small molecule numbers are involved so that fluctuations play a relevant role. In this work we study molecule number fluctuations when molecules diffuse and react. Building upon our previous works on the analysis of Fluorescence Correlation Spectroscopy experiments we derive a formula for the observation time that is needed to estimate concentrations with a given precision out of counting individual molecules.