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We investigate the feasibility of constraining parton distribution functions in the proton through a comparison with data on semi-inclusive deep-inelastic lepton-nucleon scattering. Specifically, we reweight replicas of these distributions according to how well they reproduce recent, very precise charged kaon multiplicity measurements and analyze how this procedure optimizes the determi- nation of the sea quark densities and improves their uncertainties. The results can help to shed new light on the long standing question on the size of the flavor and charge symmetry breaking among quarks of radiative origin. An iterative method is proposed and adopted to account for the inevitable correlation with what is assumed about the parton-to-hadron fragmentation functions in the reweighting procedure. It is shown how the fragmentation functions can be optimized simulta- neously in each step of the iteration. As a first case study, we implement this method to analyze kaon production data.