A disjunctive model for the synthesis of a multiproduct batch protein production plant

ALDO VECCHIETTI; JORGE MONTAGNA

Córdoba, Argentina

Congreso; 33as Jornadas Argentinas de Informática e Investigación Operativa; 2004

This paper deals with the synthesis and design of a multiproduct batch protein production process. Four products and at most 15 batch stages are involved in the synthesis and design of the multiproduct batch plant. The model includes discrete decisions about the host to be used, the type of unit operating in some of the stages, the number of parallel units operating in-phase and out-of phase at each stage, etc. A disjunctive model has been formulated for the problem. The model solution has been performed transforming the disjunctive model into Mixed Integer Nonlinear Programs (MINLP) using the Big-M and convex-hull relaxations of a disjunctive set. The results obtained and the behavior of both MINLP models used to solve the problem is shown.