BEYOND THE CLASSIC EFFECTS: ANTITUMOR ACTION OF RANITIDINE

N. MOHAMAD, T. GALARZA, G. VEDOYA, BERGOC R, G. CRICCO, G. MARTIN

Congreso; LXIII Reunión Científica Anual de la Sociedad Argentina de Investigación Clínica; 2018

Previously we demonstrated that histamine (HA) produces an increase in growth of human pancreatic xenografts of PANC-1 and BxPC3 cells in nude mice and in lung metastases. In vitro, HA hindered the activation of mesenchymal epithelial transition (a process associated with invasion and metastasis) by ionizing radiation. Literature describes the acquisition of an invasive phenotype in different tumor cells that survive gamma irradiation. The aim of this work was to evaluate the in vivo action of ranitidine (Ran) on the growth PANC-1 and BxPC3 tumors irradiated or not, as well as the appearance of metastases.PANC-1 and BxPC3 tumors were irradiated or not with 2 Gy of gamma radiation, transplanted to non-irradiated mice, and treated or not with Ran (150 mg/kg/day, p.o.). Non-irradiated PANC-1 tumors growing in RAN treated animals showed longer doubling times (p