INVESTIGADORES
MARTIN Gabriela Adriana
congresos y reuniones científicas
Título:
Antineoplasic effect of sulphonilureas. In vivo and in vitro studies.
Autor/es:
NÚÑEZ M; COCCA C; MARTIN G; CRICCO G; GUTIERREZ A; CROCI M; KIRCHHEIMER C; GARBARINO G; RIVERA E; BERGOC R
Lugar:
Iguazú, Argentina
Reunión:
Congreso; XL Reunión de la Sociedad Argentina de Investigaciones Bioquímicas; 2004
Institución organizadora:
SAIB
Resumen:
The objective of this work was to evaluate the antitumoral action of a sulphonylurea, glibenclamide (Gli), in comparison with the effect of the antiestrogen tamoxifen (Tam). In vivo studies were performed on an experimental model of mammary carcinoma induced in Sprague-Dawley rats. Both Gli (0.2 mg/Kg/day oral) and Tam (1mg/Kg/day ip), were administrated every day along 30 days when tumors reached a diameter of 6 mm. Gli treatment produced a regression of 64% of tumors, while treatment with Tam provoked a regression of 55% of tumors (P poster
