Oligoelements Se, Zn, Mn plus Lachesis Muta as radioprotectors of normal tissues and radiosensitizers of malignant cells. E.J. Crescenti,

E.S. RIVERA; M. CROCCI; V. MEDINA; G. CRICCO; N. MOHAMAD; G. MARTIN; M. NUÑEZ; R.M. BERGOC.

Madrid, Spain

Congreso; XI International Radioprotection Congress of the International Radiation Protection Association; 2004

International Radiation Protection Association

 The in vitro effect of O-LM on radiosensitivity of different human cell lines and the in vivo tolerance to high doses of ionizing radiation induced by the combination of Se, Zn and Mn plus Lachesis muta (O-LM)  was evaluated. Sprague-Dawley rats received whole-body irradiation with a single dose (2 to 15 Gy) employing  a 137Cs source of 189 TBq (7.7 Gy/min). A half of rats received daily sc O-LM starting 10 days before irradiation. These animals receiving 8, 10, and 12 Gy showed significantly higher survival versus controls (p