Methodological approaches to investigate the effects of histamine receptor targeting compounds in preclinical models of breast cancer

. DIEGO J. MARTINEL LAMAS, MELISA B. NICOUD, HELENA STERLE, GRACIELA P. CRICCO, GABRIELA A. MARTIN, GRACIELA A. CREMASCHI, HUBERT G. SCHWELBERGER, ELENA S. RIVERA, AND VANINA A MEDINA

Histamine receptors as drug targets. Series: Methods in Pharmacology and Toxicology

Springer

Año: 2017; p. 353 - 387

This book illustrates the current state-of-the-art in histamine research, with a focus on the appropriate methodologies to investigate the pharmacological properties and the therapeutic exploitation of HRs and their ligands. In addition, the range of techniques described provides an introduction to complementary cross-methodological disciplines beyond these fields. This multi-disciplinary approach is required to define the ?decision gates? that determine the development of more effective and safer therapeutic options for many forms of highly prevalent and debilitating diseases, such as asthma, dementias, dermatitis, and arthritis. Written for the  Methods in Pharmacology and Toxicology series, chapters concentrate on practical, hands-on protocols from experts in the techniques.Authoritative and thorough,  Histamine Receptors as Drug Targets seeks to aidpharmacologists, biochemists, drug discovery researchers, molecular biologists, chemists, toxicologists, lab scientists, medical doctors, principle investigators, research scientists, lab directors and technicians, as well as graduate students around the world in pursuing thestudy of this vital scientific area.