INVESTIGADORES
MARTIN Gabriela Adriana
artículos
Título:
Histamine as a potential autocrine regulator of melanoma
Autor/es:
MOLNAR EL, CRICCO G, MARTIN G, DARVAS Z, HEGYESI H, FITZSIMONS C, BERGOC R, FALUS A, RIVERA
Revista:
INFLAMMATION RESEARCH
Editorial:
Birkhauser Verlag
Referencias:
Lugar: Basel, Switzerland; Año: 2001 vol. 50 p. 102 - 103
ISSN:
1023-3830
Resumen:
Malignant tumor cells express autocrine and paracrinegrowth factors that can block immune effectiveness and facilitatethe acquisition of partial or complete growth autonomy.Recently histamine (Hi) was proved to have an important roleas a mediator in normal and malignant cell proliferation. Wehave reported that Hi behaves as an autocrine growth factorin an experimental mammary carcinoma and in pancreaticcarcinoma cells. Human melanoma cells contain highHDC activity and mRNA expression. In this work, wethus investigated the possible role of Hi in the regulation ofmelanoma growth.We postulate that endogenously produced Hi is an autocrine growth factor thatmodulates proliferation of early stage melanoma cells, while Hi produced by mast cells or surrounding tissues may contribute to a paracrine regulation of growth in the advanced metastatic stage of the disease.
