INVESTIGADORES
MARTIN Gabriela Adriana
artículos
Título:
Supression of mammay gland tumorigenesis in diabetic rats
Autor/es:
C. COCCA, A. GUTIERREZ, M. NÚÑEZ, M. CROCI, G. MARTIN, G. CRICCO, E. RIVERA, R. BERGOC
Revista:
CANCER DETECTION AND PREVENTION
Editorial:
Elsevier
Referencias:
Año: 2003 vol. 27 p. 37 - 46
ISSN:
0361-090X
Resumen:
The aim of this study was to compare mammary gland tumorigenesis in diabetic and non-diabetic rats. Streptozotocin and N-nitroso-Nmethylureawere used to induce diabetes and mammary tumors, respectively.Asuppression of mammary carcinogenesis in diabetic ratswasshown by a longer latency period, a lower number of tumors per animal and a smaller final tumor volume. An 84% of the lesions developedin diabetic animals were benign tumors. Eighty day-old diabetic rats had significantly lower plasma levels of total-IGF-I and insulin versusnon-diabetic rats. We postulate that the decrease in the total IGF-I and insulin levels during the promotion phase of carcinogenesis in thismodel plays an important role in retarding the tumor development in diabetic animals and in favoring the development of benign mammary
