INVESTIGADORES
MARTIN Gabriela Adriana
artículos
Título:
Fluoromethylhistidine inhibits tumor growth without producing depletion of endogenous histamine
Autor/es:
G. CRICCO,N. ENGEL, M. CROCCI, C. DAVIO, G. MARTIN, C. FITZSIMONS, R. BERGOC AND E. RIVERA
Revista:
INFLAMMATION RESEARCH
Editorial:
BIRKHAUSER VERLAG AG
Referencias:
Lugar: BASEL; Año: 1997 vol. 46
ISSN:
1023-3830
Resumen:
Experimental mammary carcinomas induced by N-nitrosoN-methylurea (NMU) administration express H1 and H2histamine receptors with an atypical linkage to signal transducers. In these tumors, histamine regulates cell growth as well as the expression of histidine decarboxylase(HDC) mRNA and histamine content [2]. We postulate that one of the main actions of endogenous histamine is to behave as an autocrine growth factor [3].The in vivo treatment of tumor bearing rats with the specific HDC inhibitor fluoromethylhistidine (MFMH)resulted in a marked inhibition of tumor growth as reported for other experimental tumors, but histological findings were consistent with a high histamine concentration in the tumor microenvironment rather than with histamine depletion. On this basis, we further investigate the mechanism through which MFMH inhibits tumor growth and cell proliferation in NMU-induced mammary carcinomas
