INVESTIGADORES
MARTIN Gabriela Adriana
artículos
Título:
Human pancreatic cacinoma cell line PANC-1 and the role of histamine in growth regulation.
Autor/es:
G CRICCO, G MARTIN, F LABOMBARDA, C COCCA, R BERGOC AND E RIVERA
Revista:
INFLAMMATION RESEARCH
Editorial:
BIRKHAUSER VERLAG AG
Referencias:
Lugar: BASEL; Año: 2000 vol. 49 p. 68 - 69
ISSN:
1023-3830
Resumen:
The presence of histamine (Hi) receptors has been demonstratedin different cell lines and human neoplasias and manystudies have suggested that Hi can regulate cell growth via H1and H2 receptors . We have demonstrated in an experimentalmammary carcinoma that Hi is produced by tumorcells and exerts its action as an autocrine growth factorthrough H1 and H2 membrane receptors . In this work weinvestigated the metabolic signalling pathways coupled to H1and H2 histamine receptors in the human cell line, Panc-I andthe possible role of histamine in the regulation of cell growth.
