INVESTIGADORES
MARTIN Gabriela Adriana
artículos
Título:
Design, synthesis and antitumoral activity of trisubstituted dihydrobenzo(a)carbazoles
Autor/es:
A.SEGALL, H.PAPPA, R.CASAUBON, G MARTIN, R.BERGOC AND MT PIZZORNO
Revista:
EUROPEAN JOURNAL OF MEDICAL CHEMISTRY
Editorial:
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Referencias:
Lugar: Paris; Año: 1995 vol. 30 p. 165 - 169
ISSN:
0223-5234
Resumen:
The design, synthesis, binding affinities for rabbit uterus estrogen receptors and in vivo action of two trisubstituted dihydrobenzo[a]carbazoles are reported. Relative binding affinities were similar to tamoxifen. In vivo studies in rats bearing NMU-induced mammary tumours indicate that tamoxifen (200 μg sc daily) led to 51.6% tumour regression, ovariectomy to 54.4%, and derivatives 6 and 7 (200 μg sc daily) to 50.0 and 54.8%, respectively. These experiments demonstrated that derivatives 6 and 7 are as effective as tamoxifen in the model studied
