INVESTIGADORES
MARTIJENA Irene Delia
artículos
Título:
Gabaergic Modulation of The Stress Response
Autor/es:
MARTIJENA I.D, RODRIGUEZ MANZANARES P, LACERRA C, MOLINA VA
Revista:
SYNAPSE
Editorial:
WILEY-LISS, DIV JOHN WILEY & SONS INC
Referencias:
Año: 2002 p. 86 - 94
ISSN:
0887-4476
Resumen:
the modulation of the central response to stress. In the present study we evaluate the
influence of a brief restraint exposure on GABA-stimulated chloride influx in diverse
brain areas presumed to have a major role in the mediation of emotional behaviors
following aversive stimulation.Areduced chloride uptake after stress exposure was only
observed in frontal cortex and amygdala. Moreover, rats subjected to such stressor
performed an anxiogenic behavior when exposed later to the elevated plus-maze. A
comparable behavior in the elevated plus-maze was observed between animals that were
allowed to chew during the restraint experience and those without any stressful manipulation,
suggesting that chewing served as an efficient coping behavioral strategy during
such threatening situations. In order to explore if chewing during the restraint experience
could suppress the reduction in GABA-stimulated chloride uptake induced by this
stressor, rats were allowed or not to chew during restraint and in both cases GABAstimulated
chloride influx was assayed in frontal cortex and amygdala. The finding of
this experiment showed that restrained rats that have the possibility to chew exhibited
a similar GABA-stimulated chloride uptake in cortical tissue to that shown by control,
unstressed rats. Moreover, chewing in response to restraint attenuated the reduction of
GABA-stimulated chloride uptake in amygdala, supporting the notion that chewing is
an effective coping response to restraint. These experiments suggest that a reduced
GABAergic inhibitory control in these areas could be implicated in the emotional
sequelae generated by this uncontrollable stressor and that the suppression of this
reduction seems to be associated with the occurrence of coping behavioral response to
such fear-inducing stimulus. Synapse 45:8694, 2002. © 2002 Wiley-Liss, Inc.Synapse 45:8694, 2002. © 2002 Wiley-Liss, Inc.