Pharmacokinetics of enrofloxacin following intravenous administration to greater rheas: a preliminary study.

DE LUCAS J.J.; RODRIGUEZ C.; MARTELLA M.B.; LABAQUE M.C.; NAVARRO J.L.; SAN ANDRES M.I.

RESEARCH IN VETERINARY SCIENCE

ELSEVIER SCI LTD

Año: 2005 vol. 78 p. 265 - 267

0034-5288

Abstract The pharmacokinetic behaviour of enrofloxacin (ENR) and its active metabolite ciprofloxacin (CIP) were determined in six greater rheas following a single intravenous (i.v.) dose of 15 mg/kg bw. Plasma concentrations of ENR and CIP were simultaneously determined by a HPLC/u.v. method. Following i.v. administration, the plasma drug concentrations were best fitted by an open twocompartment model with a rapid distribution phase. The high volume of distribution (Vss = 5.01 L/Kg) suggests good tissue penetration. ENR presents a high clearance (3.95 L/kg h) explaining the low AUC values (3.57 mg h/L) and a short permanence (t1/2b = 2.66 h and MRT = 1.23 h). Ciprofloxacin comprised 14% of the total fluoroquinolone (ENR + CIP).