Canine Oral Eosinophilic Granuloma Treated with Electrochemotherapy

M. TELLADO; S.MICHINSKI; N. OLAIZ; F MAGLIETTI; G. MARSHALL

Case Reports in Veterinary Medicine

Hindawi

Lugar: New Dehli; Año: 2014 vol. 2014 p. 1 - 4

A case of a canine oral eosinophilic granuloma in a 14-year-old female crossbred is described.The dog was presented with a historyof ptyalism, halitosis, local pain, decreased appetite, and blood staining noted on food and water bowls. Clinical, hematologic,and biochemical examinations, abdominal ultrasonography, and 3-view chest radiographs were performed, and no metastaseswere found. Histopathologic examination of two 6mm punch biopsies from the oral lesion revealed the presence of eosinophilicgranulomatous lesions in the submucosa. After treatment with corticosteroids and wide spectrum antibiotics no significant changesin clinical signs and lesion size were observed. Electrochemotherapy (ECT), a novel tumor treatment routinely used for cutaneousand subcutaneous tumors in human patients in the European Union since 2006, was used to treat the eosinophilic granuloma. Theprocedurewas performed under general anesthesia, followed by intravenous administration of bleomycin. Sixweeks after treatmenta complete response with disappearance of the mass and improvement of clinical signs were observed.