INVESTIGADORES
LEWKOWICZ Elizabeth Sandra
artículos
Título:
A chemoenzymatic route to prepare acyclic nucleoside analogues
Autor/es:
MARTÍN PALAZZOLO; MARIANO NIGRO; ADOLFO M. IRIBARREN; ELIZABETH LEWKOWICZ
Revista:
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Editorial:
WILEY-VCH Verlag GmbH & Co. KGaA
Referencias:
Lugar: Weinheim; Año: 2016 vol. 2016 p. 921 - 924
ISSN:
1434-193X
Resumen:
Acyclic nucleosides are potential antiviral and antitumor agents. In this work, their preparation through a novel chemoenzymatic procedure involving the N-alkylation of a nucleobase and the subsequent aldol condensation catalyzed by a dihydroxyacetone phosphate-dependant aldolase (Rabbit Muscle Aldolase, RAMA) is described.
