Organocatalytic synthesis of novel purine and pyrimidine acyclic nucleosides

MARTÍN PALAZZOLO; MARÍA PÉREZ-SÁNCHEZ; ADOLFO IRIBARREN; ELIZABETH LEWKOWICZ; PABLO DOMÍNGUEZ DE MARÍA

TETRAHEDRON LETTERS

PERGAMON-ELSEVIER SCIENCE LTD

Lugar: Amsterdam; Año: 2012 vol. 53 p. 6797 - 6800

0040-4039

Organocatalysis is assessed for the first time in the synthesis of purine and pyrimidine acyclic nucleosides providing high yields and straightforward work-up procedures. Nucleobases containing aldehydes are catalytically ligated (C–C bond formation) to acetone or to phosphonate-containing ketones by means of pyrrolidine or silica-immobilized piperazine as amine-based organocatalystS