INVESTIGADORES
LEWKOWICZ Elizabeth Sandra
artículos
Título:
Arthrobacter oxydans as biocatalyst for purine deamination
Autor/es:
ROSARIO MEDICI; ELIZABETH LEWKOWICZ; ADOLFO IRIBARREN
Revista:
FEMS MICROBIOLOGY LETTERS
Editorial:
WILEY-BLACKWELL PUBLISHING, INC
Referencias:
Año: 2008 vol. 289 p. 20 - 26
ISSN:
0378-1097
Resumen:
Deaminases are enzymes that catalyze the hydrolysis of amino groups of nucleosides or their bases. Since these enzymes play important roles in nucleotide metabolism, they are relevant targets in anticancer and antibacterial therapies. Mammalian deaminases are commercially available but the use of bacterial whole cells, especially as biocatalysts, is continuously growing because of their economical benefits. Moreover, deaminases are useful for the preparative chemoenzymatic transformation of nucleoside and base analogues into a variety of derivatives.
