INVESTIGADORES
LEWKOWICZ Elizabeth Sandra
artículos
Título:
Microbial synthesis of 2,6-diaminopurine nucleosides
Autor/es:
ROSARIO MEDICI; ELIZABETH LEWKOWICZ; ADOLFO IRIBARREN
Revista:
JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
Editorial:
Elsevier
Referencias:
Lugar: Holanda; Año: 2006 vol. 39 p. 40 - 44
ISSN:
1381-1177
Resumen:
2,6-Diaminopurine nucleosides are used as pharmaceutical drugs or prodrugs against cancer and viral diseases.The synthesis of 2,6-diaminopurine riboside, -2-deoxyriboside, -2,3-dideoxyriboside and -arabinofuranoside was efficiently carried out by transglycosylation using bacterial whole cells as biocatalysts. The preparation of 2,6-diaminopurine-2,3-dideoxyriboside catalysed by whole cellsis here reported for the first time.
