INVESTIGADORES
LEWKOWICZ Elizabeth Sandra
artículos
Título:
Microbial hydrolysis of acetylated nucleosides
Autor/es:
JULIETA PANERO; JORGE TRELLES; VALERIA RODANO; JAVIER MONTSERRAT; LUIS IGLESIAS; ELIZABETH LEWKOWICZ; ADOLFO IRIBARREN
Revista:
BIOTECHNOLOGY LETTERS
Editorial:
Springer Science
Referencias:
Lugar: Holanda; Año: 2006 vol. 28 p. 1077 - 1081
ISSN:
0141-5492
Resumen:
Enzymatic hydrolysis of acetylated nucleosides using microbial whole cells has been carried out for the first time. Unlike Candida antarctica B lipase-catalysed alcoholysis, none of the tested microorganisms displayed a common deacetylation profile. Depending on the substrate and the biocatalyst used, 5´-selective protection or mixtures of mono O-acetylated products were obtained.Candida antarctica B lipase-catalysed alcoholysis, none of the tested microorganisms displayed a common deacetylation profile. Depending on the substrate and the biocatalyst used, 5´-selective protection or mixtures of mono O-acetylated products were obtained.
